hPD-L1(2)

基因信息

基因名
Cd274

基因曾用名

B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik

NCBI ID

60533

MGI ID

1926446

Ensembl ID

ENSMUSG00000016496

Pubmed

Cd274

人類同源基因

CD274

品系描述

通過同源重組，將小鼠基因Cd274進行人源化修飾。與此相似的品系還有hPD-L1(NM-HU-00062),詳細信息請諮詢技術顧問。
應用領域：腫瘤研究；免疫治療；藥物篩選；

驗證數據

PD-L1-HU-1.png

Fig1. The expression of human PD-L1 in the peripheral blood cells derived from homozygous humanized mice were confirmed by flow cytometry analysis. 

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Fig2. Immunotype in blood , spleen and bone marrow in hPD-L1 mice. 

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Fig3. Immunotype in blood in hPD-L1 mice. 

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Fig4. Immunotype in spleen in hPD-L1 mice. 

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Fig5. Immunotype in bone marrow in hPD-L1 mice. 

PD-L1-HU-2.png

PD-L1-HU-3.png

Fig6.  In vivo anti-tumor effect of an anti-human PD-L1 antibody in the humanized PD-L1 mouse model. (Tecentriq is a monoclonal antibody specific for human PD-L1)(A)  PD-L1 humanized MC38 cells were subcutaneously implanted into humanized PD-L1 mouse model. Treatment of hPD-L1 antibody inhibited PD-L1 humanized MC38 tumor growth, demonstrating that the humanized PD-L1 mice are a good in vivo model for validating the efficacy of antibodies targeting human PD-L1. (B) Mean body weight of mice.  All quantitative data are represented as mean ± SEM.

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